![]() In vivo analysis and in vitro organoid experiments indicated that Paneth cells play a major role in driving intestinal stem cell competition and crypt clonality. Importantly, we also observed a strong correlation between the ISC competition and Paneth cell number. Moreover, differently from what observed in young mice, calorie restriction, when applied at late-life, decreases this process. By employing Confetti reporter mice, here we show that, unexpectedly, old mice have more intestinal stem cell (ISC) competition than young mice. ![]() However, the impact of aging on this process is unknown. Calorie restriction has been recently shown to increase intestinal stem cell competition and to reduce mutation fixation in young mice.
0 Comments
Leave a Reply. |